Pfffffffffft Posted May 23, 2007 Share Posted May 23, 2007 Plant extract may block cannabis addiction 22:00 22 May 2007 NewScientist.com news service Roxanne Khamsi A drug which reduces the desire for marijuana and blocks its effect on the brain has been successfully tested in rats. Scientists say the findings may translate into better therapies for cannabis addiction in humans. Rodents given a compound derived from a plant in the buttercup family lose their hankering for a synthetic version of tetrahydrocannabinol (THC) - the active compound in marijuana. The treatment also blocked a reward response in the animals' brains when they did receive synthetic THC. In the first part of the experiment, Steven Goldberg at the National Institute on Drug Abuse in Maryland, US, and his colleagues placed rats in a cage with a lever the animals could push. Each time the rats leaned on the lever, they received a dose of the synthetic THC through a small tube running into their body. Over a period of three weeks the rats learned to enjoy the effects of synthetic THC and frequently self-administered the drug. By comparison, rats that received saline solution did not press the lever often. Goldberg's team then injected the rats with a compound derived from the seeds of the Delphinium brownii plant, which is in the buttercup family. The compound, known as methyllycaconitine (MLA), had a dramatic effect on the animals' behaviour. Blocking dopamine On the day that they received MLA they pushed the lever for synthetic THC 70% less than before. The drug did not seem to otherwise change the rats' movement and coordination, and had no other apparent side effects. The scientists also took a close look at the effects of MLA on the rats' brains. They used a technique called microdialysis to take tiny fluid samples from a reward-signalling area of the brain known as the nucleus accumbens, which sits near the base of the head. When rats receive synthetic THC, levels of the reward chemical dopamine normally shoot up in the nucleus accumbens - but MLA blocked the release of dopamine in this brain region. "The increases in dopamine are virtually non-existent because of MLA," says Goldberg. He adds that MLA did not lower dopamine levels below normal amounts. This is important, says Goldberg, because it suggests that a similar therapy for humans would not interfere with normal reward signalling in the brain. He notes that the drug Rimonobant, which makes monkeys less likely to self-administer THC, has been linked to depression in humans. The exact mechanism by which MLA works remains a mystery. Scientists know that MLA binds to specific cell receptors in the brain called alpha-7 nicotinic receptors. They speculate that cannabis indirectly triggers these receptors, but cannot do so when the receptors are blocked by MLA. Human potential There is a genuine need for medications to help cannabis addicts overcome their drug problem, according to Goldberg: "About 10% of the people who experiment with it go on to heavy use and have trouble voluntarily giving it up. I think there is a proportion of the population who need ways to make them stop." Drug-makers have recently made medications such as Chantix available to help people quit tobacco smoking. But researchers say that these drugs affect different nicotinic receptors than those triggered by THC. And while some people have pushed Rimonobant as a possible remedy for addiction, Goldberg says that more options - such as one based on MLA - must be explored: "Each patient is different and what works in one might not work in another." Journal reference: Journal of Neuroscience (DOI: 10.1523/JNEUROSCI.0027-07.2007) POOPS LINK- http://www.newscientist.com/article/dn11904-plant-extract-may-block-cannabis-addiction-.html Quote Link to comment Share on other sites More sharing options...
Guest R@ndomH3ro Posted May 23, 2007 Share Posted May 23, 2007 Re: THERE IS HOPE FOR YOU POT HEADS.. wow.... Quote Link to comment Share on other sites More sharing options...
Mauler5150 Posted May 23, 2007 Share Posted May 23, 2007 Re: THERE IS HOPE FOR YOU POT HEADS.. But some people are just addicted to the routine of chasing weed, packign cones, and smoking them, not just the effects of the weed. They have to find a way to make the people replace these habits as well, which won't happen. Quote Link to comment Share on other sites More sharing options...
Cool Water Posted May 23, 2007 Share Posted May 23, 2007 Re: THERE IS HOPE FOR YOU POT HEADS.. ughhh. i dont want to stop but its killed my motivation :/ Quote Link to comment Share on other sites More sharing options...
Some1 Posted May 23, 2007 Share Posted May 23, 2007 Re: THERE IS HOPE FOR YOU POT HEADS.. Who the fuck gets addicted to weed!? If you are addicted to smoking pot you should prolly think about stopping your crack heroin and meth addiction first... Quote Link to comment Share on other sites More sharing options...
SADDAM HUSSEIN Posted May 23, 2007 Share Posted May 23, 2007 Re: THERE IS HOPE FOR YOU POT HEADS.. my shrink wanted me to take that shit 11 years ago.. i told him fuck that.. smoked and got up... lol he also told me that people doing graffiti was like dogs pissing and marking thier spot... i told him yup and always came to group session stoned. had some hot chicks. my shrink started to realize im a genius, his bitch of a wife who's too busy writing books to fuck her husband thinks im nuts. Quote Link to comment Share on other sites More sharing options...
SADDAM HUSSEIN Posted May 23, 2007 Share Posted May 23, 2007 Re: THERE IS HOPE FOR YOU POT HEADS.. that pill is designed so that you would just lose the love for it.. i saw the good stuff about it... like i coulda stopped smokin herb, then i woulda realized that im just a robot that studies hard in school, quits graf and becomes that prosecuter. cause dammit, if there is one thing i hate, its potheads and graffiti artists. i'd like to mention that im stoned right now. Quote Link to comment Share on other sites More sharing options...
Dirty_habiT Posted May 23, 2007 Share Posted May 23, 2007 Re: THERE IS HOPE FOR YOU POT HEADS.. fuck that I need a blunt... haha, just kidding. That is cool though, I have never heard of a drug that can help marijuana users out...before now. Then again, I'm against using any kind of "crutch" to quit... I refuse to use nicotine lozenges, gum, patches, etc. Quote Link to comment Share on other sites More sharing options...
kr0n1k Posted May 23, 2007 Share Posted May 23, 2007 Re: THERE IS HOPE FOR YOU POT HEADS.. they should just bring back the t pill Quote Link to comment Share on other sites More sharing options...
heavyLox Posted May 23, 2007 Share Posted May 23, 2007 Re: THERE IS HOPE FOR YOU POT HEADS.. lets pop pills instead of smoking some tweed; sounds like a good idea, cause the government will make money that way... Good plan. Sign me up for the, 'ill stick with me weed-pot". Quote Link to comment Share on other sites More sharing options...
*PROTOCOL* Posted May 23, 2007 Share Posted May 23, 2007 Re: THERE IS HOPE FOR YOU POT HEADS.. When I wanted to quit smoking pot I just stopped, havent smoked in years. When I NEEDED to stop, for jobs, probation etc... I also just quit doing it. Fuck that, pot isn't even that serious, learn to use your will power. Quote Link to comment Share on other sites More sharing options...
*PROTOCOL* Posted May 23, 2007 Share Posted May 23, 2007 Re: THERE IS HOPE FOR YOU POT HEADS.. Also why take something to block a desire. If its something you desire, do it. I don't know anybody that pawns all their shit and is living on the streets for smoking weed. I guess it just sounds like bullshit to me. Quote Link to comment Share on other sites More sharing options...
ViolentByDesign Posted May 23, 2007 Share Posted May 23, 2007 Re: THERE IS HOPE FOR YOU POT HEADS.. I thought it was going to be about pills containing straight THC extracts. There is seriously someone in the world 'addicted' to weed? I stopped puffin for a while because it was making me crazy paranoid and it wasn't hard at all. Then once I got a job and it stopped making me paranoid I realized that it just had an effect on my negative mindset and hopped back on the green train. If someone says they are addicted to weed then that is just ridiculous. I stopped out of the blue after about 6 years of smoking multiple times every day and nothing was different and I didn't feel different. Pussies. Quote Link to comment Share on other sites More sharing options...
Harvey Wallbanger Posted May 23, 2007 Share Posted May 23, 2007 Re: THERE IS HOPE FOR YOU POT HEADS.. "Have you ever sucked dick for weed?" Sorry, it had to be said. Quote Link to comment Share on other sites More sharing options...
DA KID MERO Posted May 23, 2007 Share Posted May 23, 2007 Re: THERE IS HOPE FOR YOU POT HEADS.. NIGGAS REALLY HAVE "THERAPISTS" ?? I WISH I HAD ENOUGH BREAD TO PAY A NIGGA TO LISTEN TO ME COMPLAIN AND PRESCRIBE ME STICKS AND SHIT. Quote Link to comment Share on other sites More sharing options...
tango 24 Posted May 23, 2007 Share Posted May 23, 2007 Re: THERE IS HOPE FOR YOU POT HEADS.. ha therapist i quit a while back started again recently its kind of lost its appeal Quote Link to comment Share on other sites More sharing options...
!@#$% Posted May 23, 2007 Share Posted May 23, 2007 Re: THERE IS HOPE FOR YOU POT HEADS.. replace your addiction with an obsessive love of cheez its Quote Link to comment Share on other sites More sharing options...
Harvey Wallbanger Posted May 23, 2007 Share Posted May 23, 2007 Re: THERE IS HOPE FOR YOU POT HEADS.. The two sort of go hand in hand. Quote Link to comment Share on other sites More sharing options...
mr. Niceguy Posted May 23, 2007 Share Posted May 23, 2007 Re: THERE IS HOPE FOR YOU POT HEADS.. Define the term pothead, just to see if I fall into that stereotype.Wait..... what are we talking about ???? Quote Link to comment Share on other sites More sharing options...
Skilla54 Posted May 23, 2007 Share Posted May 23, 2007 Re: THERE IS HOPE FOR YOU POT HEADS.. my anti weed drug is beer .... i actualkly i just ate a pot browny bought form the old lady im kinda fucked da did Quote Link to comment Share on other sites More sharing options...
wayne hits Posted May 23, 2007 Share Posted May 23, 2007 Re: THERE IS HOPE FOR YOU POT HEADS.. Quote Link to comment Share on other sites More sharing options...
.coma Posted May 23, 2007 Share Posted May 23, 2007 Re: THERE IS HOPE FOR YOU POT HEADS.. that pill is designed so that you would just lose the love for it.. i saw the good stuff about it... like i coulda stopped smokin herb, then i woulda realized that im just a robot that studies hard in school, quits graf and becomes that prosecuter. cause dammit, if there is one thing i hate, its potheads and graffiti artists. i'd like to mention that im stoned right now. i feel bad for all the people going through this life SOBER:( Quote Link to comment Share on other sites More sharing options...
Hayabusa Posted May 23, 2007 Share Posted May 23, 2007 Re: THERE IS HOPE FOR YOU POT HEADS.. have you ever looked at the back of a dollar bill? have you ever looked at the back of a dollar bill............ on weeeeeeeeeeeeeeed? Quote Link to comment Share on other sites More sharing options...
blackboatshoes Posted May 23, 2007 Share Posted May 23, 2007 Re: THERE IS HOPE FOR YOU POT HEADS.. o'dweeds!!! haha. Quote Link to comment Share on other sites More sharing options...
papa_dukes Posted May 23, 2007 Share Posted May 23, 2007 Re: THERE IS HOPE FOR YOU POT HEADS.. hahaaaa stonahhh :rolleyes: :rolleyes: Quote Link to comment Share on other sites More sharing options...
*PROTOCOL* Posted May 23, 2007 Share Posted May 23, 2007 Re: THERE IS HOPE FOR YOU POT HEADS.. i feel bad for all the people going through this life SOBER:( Dont get me wrong I love drugs, but I still think it's stupid when someone says something along the lines of this. Quote Link to comment Share on other sites More sharing options...
Tails0nE Posted May 23, 2007 Share Posted May 23, 2007 Re: THERE IS HOPE FOR YOU POT HEADS.. When I wanted to quit smoking pot I just stopped, havent smoked in years. When I NEEDED to stop, for jobs, probation etc... I also just quit doing it. Fuck that, pot isn't even that serious, learn to use your will power. exacley.... i quit a couple time before for jobs n shit n just for the hell of it.. it sucks though when everyone in your family smokes n when your quitting you smell it like 3 to 4 times daily... shits not cool... Quote Link to comment Share on other sites More sharing options...
CALIgula Posted May 23, 2007 Share Posted May 23, 2007 Re: THERE IS HOPE FOR YOU POT HEADS.. Quote Link to comment Share on other sites More sharing options...
papa_dukes Posted May 23, 2007 Share Posted May 23, 2007 Re: THERE IS HOPE FOR YOU POT HEADS.. if you use a bong.........its healthier Quote Link to comment Share on other sites More sharing options...
*PROTOCOL* Posted May 23, 2007 Share Posted May 23, 2007 Re: THERE IS HOPE FOR YOU POT HEADS.. Whoah dude, its like, a fight scene from that one crazy spaceship movie dude. What movie is that dude? Quote Link to comment Share on other sites More sharing options...
Recommended Posts
Join the conversation
You can post now and register later. If you have an account, sign in now to post with your account.