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Technical Links > Health Guidelines > Toluene

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Disclaimer: The information contained in these guidelines is intended for reference purposes only. It provides a summary of information about chemicals that workers may be exposed to in their workplaces. The information contained in these guidelines is current as of date of publication (September, 1996); recommendations may be superseded by new developments in the field of industrial hygiene. Readers are therefore advised to regard these recomendations as general guidelines and to determine whether new information is available.

 

OCCUPATIONAL SAFETY AND HEALTH GUIDELINE FOR TOLUENE

 

INTRODUCTION

 

This guideline summarizes pertinent information about toluene for workers and employers as well as for physicians, industrial hygienists, and other occupational safety and health professionals who may need such information to conduct effective occupational safety and health programs. Recommendations may be superseded by new developments; readers are therefore advised to regard these recommendations as general guidelines and to determine periodically whether new information is available.

 

SUBSTANCE IDENTIFICATION

 

* Formula

 

C(6)H(5)CH(3)

 

* Structure

 

(For Structure, see paper copy)

 

* Synonyms

 

Toluol; phenylmethane; methylbenzene; Tolu-Sol; methylbenzol; methacide.

 

* Identifiers

 

1. CAS: 108-88-3.

 

2. RTECS: XS5250000.

 

3. DOT UN: 1294 27.

 

4. DOT label: Flammable liquid.

 

* Appearance and odor

 

Toluene is a flammable, colorless liquid with an aromatic odor like that of benzene.

 

CHEMICAL AND PHYSICAL PROPERTIES

 

* Physical data

 

1. Molecular weight: 92.13.

 

2. Boiling point (760 torr): 111 degrees C (231 degrees F).

 

3. Specific gravity (water = 1): 0.87 at 20 degrees C (68 degrees F).

 

4. Vapor density (air = 1 at boiling point of toluene): 3.14.

 

5. Freezing point: -94.5 degrees C (-138 degrees F).

 

6. Vapor pressure at 20 degrees C (68 degrees F): 22 torr.

 

7. Solubility: Nearly insoluble in water; miscible with alcohol, chloroform, ether, acetone, glacial acetic acid, and carbon disulfide.

 

8. Evaporation rate (butyl acetate = 1): 2.24.

 

* Reactivity

 

1. Conditions contributing to instability: Heat, sparks, and open flame.

 

2. Incompatibilities: Contact of toluene with strong oxidizing agents may cause fires and explosions. In the presence of nitric acid, and especially in the presence of sulfuric acid, toluene produces dangerously explosive compounds.

 

3. Hazardous decomposition products: Toxic gases (such as carbon dioxide and carbon monoxide) may be released in a fire involving toluene.

 

4. Special precautions: Toluene attacks some coatings and some forms of plastic and rubber.

 

* Flammability

 

The National Fire Protection Association has assigned a flammability rating of 3 (severe fire hazard) to toluene.

 

1. Flash point: 4 degrees C (40 degrees F) (closed cup).

 

2. Autoignition temperature: 480 degrees C (896 degrees F).

 

3. Flammable limits in air (percent by volume): Lower, 1.2; upper, 7.1.

 

4. Extinguishant: Use carbon dioxide, dry chemical, or foam to extinguish fires involving toluene. Do not use a solid stream of water because this will scatter and spread the fire. Water may be used to cool fire-exposed containers. If a leak or spill has not ignited, water spray may be used to disperse vapors and to protect persons attempting to stop the leak.

 

Fires involving toluene should be fought upwind and from the maximum distance possible. Keep unnecessary people away; isolate hazard area and deny entry. Emergency personnel should stay out of low areas and ventilate closed spaces before entering. Vapor explosion and poison hazards may occur indoors, outdoors, or in sewers. Vapors may travel to a source of ignition and flash back. Containers of toluene may explode in the heat of the fire and should be moved from the fire area if it is possible to do so safely. If this is not possible, cool containers from the sides with water until well after the fire is out. Stay away from the ends of containers. Personnel should withdraw immediately if a rising sound from a venting safety device is heard or if there is discoloration of a container due to fire. Dikes should be used to contain fire-control water for later disposal. If a tank car or truck is involved in a fire, personnel should isolate an area of a half a mile in all directions. Firefighters should wear a full set of protective clothing, including a self-contained breathing apparatus, when fighting fires involving toluene. Firefighters' protective clothing may provide limited protection against fires involving toluene.

 

* Warning properties

 

The best estimate of the odor recognition/detection thresholds for toluene are 1.6/11.0 parts per million (ppm) parts of air.

 

* Eye irritation properties

 

No information is available on the specific concentration of toluene at which eye irritation begins; however, contact of the eyes with a toluene vapor concentration of 100 ppm for several hours is reported to cause slight irritation.

 

EXPOSURE LIMITS

 

The current OSHA PELs for toluene are 100 ppm (375 milligrams per cubic meter (mg/m3)) as an 8-hour time-weighted average (TWA) concentration and 150 ppm (560 mg/m3) as a 15-minute TWA short-term exposure limit (STEL). A STEL is the maximum 15-minute concentration to which workers may be exposed during any 15-minute period of the working day [29 CFR 1910.1000, Table Z-1-A]. The National Institute for Occupational Safety and Health (NIOSH) recommended exposure limit (REL) for toluene is 100 ppm as a TWA for up to an 8-hour workshift and a 40-hour workweek and 200 ppm (750 mg/m3) as a 10-minute ceiling limit [NIOSH 1988a]. NIOSH also concurs with the limits established by OSHA [NIOSH 1988b]. The American Conference of Governmental Industrial Hygienists (ACGIH) has assigned toluene threshold limit values (TLVs) of 100 ppm as a TWA for a normal 8-hour workday and a 40-hour workweek and 150 ppm as a STEL for periods not to exceed 15 minutes [ACGIH 1991, p. 35]. The OSHA limits are based on the risk of hepatotoxic and nervous system effects associated with exposure to toluene [54 FR 2432], and the NIOSH limit is based on the risk of central nervous system depression associated with exposure to toluene.

 

HEALTH HAZARD INFORMATION

 

* Routes of exposure

 

Exposure to toluene can occur via inhalation, ingestion, and eye or skin contact.

 

* Summary of toxicology

 

1. Effects on Animals: In animals, toluene is an irritant of the eyes, upper respiratory tract, and skin, and a central nervous system depressant; it also causes fetotoxic and developmental effects. Its acute lethality is low: the oral LD(50) in the rat is 5000 mg/kg, the LC(50) in the same species is 4000 ppm for 4 hours, and the dermal LD(50) in the rabbit is 12,124 mg/kg [RTECS 1989]. Applied to the skin of rabbits, toluene causes mild to moderate irritation, depending on dose and duration of contact; in contact with the eyes, toluene causes reversible irritation [RTECS 1989]. In rats (as in most other species), the nervous system is the most sensitive; short-term exposure to 1250 ppm toluene affected coordination [EPA 1987, p. 6]. Cats exposed to a 7800-ppm concentration for 80 minutes developed tremors and became prostrate; extending the duration of exposure to 2 hours led to narcosis in these animals [Carpenter et al. 1976]. Rats exposed 7 hours/day, 5 days/week for 6 weeks to a 200-ppm concentration showed signs of slight lung irritation, while those exposed to 600 ppm on the same regimen showed renal effects at autopsy [EPA 1987, p. 6]. Female rats exposed to 100 or 300 ppm toluene for 2 years had reduced blood hematocrit values, while those exposed to 300 ppm showed an increase in corpuscular hemoglobin concentration [EPA 1987, p. 6]. By oral administration, toluene causes fetotoxicity and developmental abnormalities in mice, and by inhalation it causes these effects in mice and rats [RTECS 1989].

 

2. Effects on Humans: Toluene is a central nervous system depressant and an irritant of the eyes, mucous membranes, and skin in humans. In contact with the eyes, toluene causes reversible corneal injury; prolonged skin contact causes defatting and dermatitis [Hathaway, Proctor, Hughes, and Fischman 1991, p. 546]. Volunteers exposed to a 200-ppm concentration of toluene for 8 hours experienced mild upper respiratory tract irritation; at 400 ppm, subjects experienced mild eye irritation and tearing and laughed inappropriately; at 600 ppm, the volunteers developed slight nausea and lassitude; and at 800 ppm, they experienced drowsiness, incoordination, and a metallic taste in the mouth [Clayton and Clayton 1981-1982, p. 3283; Hathaway, Proctor, Hughes, and Fischman 1991, p. 546]. Some volunteers exposed to a 100-ppm concentration of toluene for 6 hours reported eye and nose irritation, and some reported headache and dizziness [Hathaway, Proctor, Hughes, and Fischman 1991, p. 546]. An employee exposed to very high (concentration not specified) levels of toluene for 18 hours collapsed and lost consciousness; this individual showed clinical signs of liver and kidney damage but later recovered [Clayton and Clayton 1981-1982, p. 3285]. Painters exposed repeatedly to toluene at concentrations between 100 and 1100 ppm developed enlarged livers, macrocytosis, a moderate decrease in erythrocyte count, and lymphocytosis, but showed no signs of leukopenia [ACGIH 1986, p. 578]. Studies of workers chronically exposed to toluene or mixtures of solvents containing toluene have shown minor abnormalities in neuropsychological test results and decrements in performance, although a recent study of rotogravure printers exposed to an average toluene concentration of 117 ppm for approximately 22 years detected no significant neurophysiologic or psychological differences compared with these parameters in controls [Hathaway, Proctor, Hughes, and Fischman 1991, p. 546].

 

* Signs and symptoms of exposure

 

1. Acute exposure: The signs and symptoms of acute exposure to toluene include redness and inflammation of the eyes and eyelids, runny nose, scratchy throat, fatigue, weakness, incoordination, confusion, headache, dizziness, and drowsiness.

 

2. Chronic exposure: The signs and symptoms of chronic exposure to toluene include incoordination; tremors; impaired speech, vision, hearing, or memory; nausea; lack of appetite; and defatting of the skin.

 

* Emergency procedures:

 

In the event of an emergency, the rescuer should don appropriate personal protective equipment, remove the victim from further exposure, send for medical assistance, and initiate the following emergency procedures:

 

1. Eye exposure: If toluene or a solution containing this substance gets into the eyes, immediately flush the eyes with large amounts of water for a minimum of 15 minutes, lifting the lower and upper lids occasionally. If irritation persists, get medical attention as soon as possible.

 

2. Skin exposure: If toluene or a solution containing this substance contacts the skin, the contaminated skin should be flushed with large amounts of water for at least 15 minutes, followed by washing with soap and water. If irritation persists, get medical attention.

 

3. Inhalation: If toluene vapors are inhaled, move the victim at once to fresh air and get medical care as soon as possible. If the victim is not breathing, perform cardiopulmonary resuscitation; if breathing is difficult, give oxygen. Keep the victim warm and quiet until medical help arrives.

 

4. Ingestion: DO NOT INDUCE VOMITING. If toluene or a solution containing this substance is ingested, give the victim several glasses of water to drink. Get medical help immediately. Keep the victim warm and quiet until medical help arrives.

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Since each individual’s immune system is different, it is hard to determine how much exposure to paint fumes it takes to have damaging effects. In most cases, it takes years of exposure to affect the brain. But in some rare instances, a single exposure to paint fumes has left impairment, depending on the level of exposure, current health, and the solvents exposed to. And, of course, there are those who are never affected.

 

 

Compared to twenty-five years ago, the solvent emissions in a gallon of paint are up to ninety percent less. However, most paints still contain harmful fumes if inhaled or absorbed. In fact, most of us are unaware of the effects that one coat of paint may have. Low levels of vapors from either formaldehyde, benzene, butane, propane, and fluorinated hydrocarbons found in can or spray paints are released on a daily basis for the first thirty days after application. But even year’s later small amounts of toxic fumes can continue to leak into the air. Over a period, exposure to these fumes can be harmful to the brain.

 

 

Another danger is exposure to lead-based paint. Although most lead-based paints have been pulled from markets, over eighty percent of homes built before 1978 still have lead paint in them. Lead is a poisonous heavy metal. If lead-based paint is disturbed by sanding, scraping, or abrading, fumes and particles may be produced. These fumes and paint chips, if inhaled or ingested over time, can cause lead poisoning and change brain chemistry. Lead poisoning can be contracted at any age but has a greater impact on children who can suffer learning disabilities, visual and hearing impairments, IQ deficiencies, and behavior problems. Keep in mind that the fetus of a pregnant woman can be affected as well. Lead poisoning may occur gradually with no obvious symptoms. If you suspect lead-based paint, have the paint tested. Other preventative measures are to have the paint removed or coated with a sealant or gypsum wallboard, but try not to stir up fumes or dust. Wiping the surface periodically with a high phosphorous cleaning solution can be helpful if no other alternative. Painting over the lead-based paint with non-lead paint does not prove to be effective since eventually the paint can wear off or produce a mixture of toxic fumes.

 

 

What happens to the brain with over-exposure to paint fumes is the destruction of brain cells and disruption in normal brain activity. When toxic paint fumes are inhaled (be aware that paint can soak into the skin and cause the same problems as inhaling the vapors), these toxins target fatty tissues such as the myelin sheath of the brain. Over time, this protective covering of the brain becomes removed, reducing brain cells and damaging axons. Presently, the process of demyelination is irreversible and decreases nervous system activity effecting neurological and behavioral functions. Abnormalities in brain areas are apparent such as, if there is damage to the cerebellum, involved movement can be affected, or if the cerebral cortex is damaged, cognitive dysfunctions can occur. Also, brain-imaging techniques, such as magnetic resonance imaging (MRI), can detect lesions or size reduction in areas of the brain including the cerebral cortex, cerebellum, and brainstem.

 

 

Some common signs and symptoms of over-exposure to paint fumes is dizziness, headaches, frequent runny nose or eyes. In severe cases, you may experience difficulty breathing, tremors or shaky hands, irritability, memory loss, or slurred speech. If you experience any of these symptoms after exposure to paint fumes, consult your physician immediately.

 

 

A serious solvent abuse among teens, and some adults, is called “Huffing”. This is where paint fumes, especially from spray paints, are deeply inhaled. The toxins enter the blood stream quickly and then are distributed throughout the brain and body. The fumes have a direct effect on the central nervous system consisting of the brain and spinal cord giving the person a high. Every huff is dangerous and can lead to brain damage, or worse Sudden Sniffing Death (SSD). SSD can occur when the inhaled fumes take the place of oxygen in the lungs and brain of the central nervous system.

 

 

Doctors have found correlations with over-exposure of paint fumes contributing to chronic or terminal illnesses related to the brain. One is called “the burning brain” effect, which is an exposure to a combination of toxic fumes or heavy metals found in a number of materials including lead-based paint or spray paint used for painting automobiles. When exposed to this combination of toxic fumes or solvents, over a period they may cause what doctors refer to as a synergistic effect, or greater effect than absorbing just one toxin. Since toxins in the brain cause free radical damage, inflammation occurs forming holes in the blood-brain barrier and stimulating a burning sensation. In order to relieve this inflammation and burning the toxins must be removed; however, there still may be some form of permanent brain damage afterwards, usually to the central nervous system. Other serious medical problems that can possibly develop from over-exposure to paint fumes are autoimmune diseases such as Multiple Sclerosis, brain cancer, and Alzheimer’s or Parkinson’s disease.

 

 

Knowing the potential hazard of exposure to paint fumes, you’ll want to take every precaution with your painting project, big or small. You should always use a respirator when painting and have proper ventilation. It is best to seal off the room or area you are painting to keep fumes from floating into other areas. Wearing thick chemical resistant gloves is a good way to prevent paint from getting on your hands and toxins absorbing into the skin. Also, you should wear full clothing to prevent further skin exposure, and change your clothes directly after painting. If possible, you should try to avoid the painted area for at least two days. One way to keep the air in your home or office clean is to buy some toxin absorbing plants. More than one hundred plants were tested and proved to purify toxins in the air at a slow rate.

 

 

Though not scientifically proven, physicians have noticed taking vitamins and herbs can help relieve some of the effects that toxins have on our body. There are supplements that can help remove toxins from the body, such as Milk Thistle supplement, and other needed vitamins are antioxidants such as vitamin C, zinc, selenium, and vitamin E.

 

 

With evidence that there is risk with exposure to harmful paint fumes, taking extra precaution, no matter the cost, is worth preventing life-long effects to the brain.

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