I'd say yes.
If you talk to people who have lost limbs, I would say there personality does change. If not drastically. I'm sure some people are mentally tougher then others, so there would be some exceptions to this, but overall I don't think so.
If you want to get into Eugenics and what not. That is a pretty scary subject. You can basically create the person you want you're children to be. Not to mention the other things if you aren't capable of doing now, will be in the future. Basically creation of mutants.