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Get it off me!!!! AAggghhh, what the fuck!?!!?

Discussion in 'Channel Zero' started by Dirty_habiT, Sep 11, 2002.

  1. Dirty_habiT

    Dirty_habiT Dirty Dozen Crew

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    Get it off me!!!! AAggghhh, what the fuck!?!!?

    Discussion started by Dirty_habiT - Sep 11, 2002

    By Keith Mulvihill

    NEW YORK (Reuters Health) - Scientists have successfully inserted a foreign gene into the DNA of mice that was later incorporated into growing hair shafts.

    "This will allow us to search for genes that will give a cosmetic benefit as well as potential therapeutic benefits when inserted into the hair follicle," said the study's lead author Dr. Robert M. Hoffman of AntiCancer Inc., a San Diego, California-based biotechnology company.

    While the green fluorescent protein (GFP) gene, which comes from jellyfish, has no medical significance, the main goal was to determine if the researchers could make transgenic mouse hair.

    The mouse genome did indeed take up the GFP gene, researchers report in the early edition of the Proceedings of the National Academy of Sciences.

    Hoffman and his colleagues began by inserting GFP into an inactivated virus. Then they removed small bits of skin from mice and treated their skin with the enzyme collagenase. The collagenase made the hair follicles in the skin accessible to the virus, which was used to "micro-inject" the DNA containing the GFP gene, Hoffman explained.

    "This allowed the efficient transfer of the GFP gene to the hair follicles," he said. The treated fragments of skin were then transplanted onto other mice.

    "The gene-modified hair follicles then produced modified hair shafts, which were easily detected by GFP fluorescence," Hoffman said.

    Roughly 75% of the mice hair follicles contained the new gene, the report indicates.

    With regard to cosmetic implications, Hoffman noted that patients undergoing hair transplants, where skin fragments could be treated in a similar fashion as in the mouse experiment, could use this technology. This would require that the researchers discover genes that confer cosmetic benefits, he pointed out.

    In addition, the hair follicle "could also be used as a 'factory' to produce therapeutic products as well," Hoffman said.

    The therapeutic gene could be chosen depending on the disease one wishes to treat. The hair follicle could express this gene and produce the therapeutic product, he noted.

    "It must be emphasized that this early technology is now appropriate only in animal experiments and not for use in humans. We will exploit this technology to discover useful cosmetic and therapeutic genes that can be transferred in this manner or perhaps modifying the technology to transfer the genes directly without removal of the skin," Hoffman told Reuters Health.

    "It also must be emphasized that any type of gene transfer in humans will be very carefully scrutinized by the FDA before approval," he added.

    "It is difficult to speculate when such technology would be applicable to human trials," Hoffman stated. "A guess would be in the order of 5 years."

    SOURCE: Proceedings of the National Academy of Sciences 2002;10.1073/pnas.192453799.








    I don't think that I can sleep well at night anymore, knowing that these things could be at large.
     
    Dirty_habiT - Rank: Dirty Dozen Crew - Messages:
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  2. kissmyass#1

    kissmyass#1 12oz Senior Member

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    kissmyass#1 - Replied Sep 11, 2002

    the world is going to be taken over by those things
     
    kissmyass#1 - Rank: 12oz Senior Member - Messages:
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  3. T.T Boy

    T.T Boy Dirty Dozen Crew

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    T.T Boy - Replied Sep 11, 2002

    http://www.act-solutions.com/images/phil-k.jpg'>

    aint that a bitch
     
    T.T Boy - Rank: Dirty Dozen Crew - Messages:
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  4. dahighlifdhl

    dahighlifdhl 12oz Senior Member

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    dahighlifdhl - Replied Sep 11, 2002

    and it is starting right now^
     
    dahighlifdhl - Rank: 12oz Senior Member - Messages:
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  5. Greedy

    Greedy Guest

    Greedy - Replied Sep 11, 2002

    Someone has a littel to much free time.
     
  6. angry xbox

    angry xbox Guest

    angry xbox - Replied Sep 11, 2002

    what the fuck where is makros?
     
  7. Dirty_habiT

    Dirty_habiT Dirty Dozen Crew

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    Dirty_habiT - Replied Sep 11, 2002

    Hi swizel.
     
    Dirty_habiT - Rank: Dirty Dozen Crew - Messages:
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  8. serpent of the light

    serpent of the light 12oz Member

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    serpent of the light - Replied Sep 11, 2002

    can somebody summarize that for me? it started out interesting momentarily, and then i just started not reading it...
     
    serpent of the light - Rank: 12oz Member - Messages:
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