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dosoner

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    bicicletas

    in Lifestyle

    Posted

    i got an old raleigh girls bike that is pretty hot, not sure of the year because the sn isnt completly readable.

     

    im gonna have to post up the schwinn racer and the raleigh

    bicicletas

    in Lifestyle

    Posted

    GIVE ME SOME HELP 12OZ...

     

    OR THIS 3 SPEED CRUISER???

     

    im leanin towards the first or the third but i mostly want something to ride quick in downtown traffic back from work in...............

     

     

    the 3 speed is hot. thats a schwinn racer right? looks like the 66 schwinn racer i got parked in my living room.

    bicicletas

    in Lifestyle

    Posted

    Everyone will still knnow you bought a 300 dollar bike off ebay. you aren't going to fool anyone. why would you pay more than the frame is woth to have it powdercoated. rattlecan that shit.

     

     

     

    this man speaks the truth!

    Ethics Of...

    in Channel Zero

    Posted

    i have a job interview in 3 hours and im still drunk.

     

    i been at work for 8 hours and am drunk.

     

    but being pretty much my own boss and all, there isnt really anyone to tell me that i cant drink on the job

     

    you aint hard.

    Rollingggggggggggggggg

    in Channel Zero

    Posted

    i pulled this straight off erowid:

     

     

    Reduction of Effects

     

    SSRIs tend to cause reduced physiological and mental effects when taken before MDMA. A study for which there was a poster at the College on Problems of Drug Dependence in June of 2002, administered 20mg Paroxetine (Paxil, a common dosage) orally to subjects for 3 days before administering MDMA. Subjects had reduced experiential and physiological responses to the MDMA. See http://www.erowid.org/references/refs_view.php?ID=1388.

     

    An important study by Liechti et al., concerning the effects of SSRI pretreatment on subjective MDMA effects in humans, administered Citalopram (an SSRI) at 40mg by IV and found that the Citalopram reduced physiological and emotional responses:

     

     

    "The main result of this study is that the psychoactive effects of 1.5 mg/kg MDMA were substantially attenuated by pretreatment with the SSRI citalopram (40 mg iv). Citalopram inhibited most of the psychological effects of MDMA. MDMA-induced increases in positive mood, derealization and depersonalization phenomena, thought disorder, and the loss of thought and body control were all attenuated by citalopram pretreatment. MDMA-evoked intensification of sensory perception, changes in the meaning of percepts, and subjectively facilitated imagination were also inhibited by citalopram as compared to MDMA alone. Citalopram alone also lowered scores on some scales compared to placebo. Most of these changes, however, were clearly due to side effects of citalopram such as fatigue, headache, and nausea, which influenced the mood rating. MDMA also produced marked increases in emotional excitability and sensitivity that, however, were not reduced by citalopram."

    See http://www.erowid.org/references/refs_view.php?ID=392.

     

    "We investigated the effect of citalopram pretreatment (40 mg i.v.) on vegetative and cardiovascular effects of MDMA (1.5 mg/kg p.o.) in a double-blind placebo-controlled study in 16 healthy volunteers. MDMA moderately increased blood pressure and heart rate, slightly elevated body temperature and produced a broad range of acute and shortterm side-effects. Citalopram reduced all these MDMA-induced physiological changes except for body temperature."

    See http://www.erowid.org/references/refs_view.php?ID=1073.

    A further relevant study, from the Spanish group studying MDMA In humans, is:

     

    Segura M, Farré M, Pichini S, Peiró AM, Roset PN, Ramírez A, Ortuño J, Pacifici R, Zuccaro P, Segura J, de la Torre R (2004) Contribution of CYP2D6 to 3,4-methylenedioxymethamphetamine (MDMA) disposition in humans: use of paroxetine as a metabolic inhibitor probe. Clin Pharmacokin (in press).

     

    As of Feb 2005 this study is still in press, but in a different paper Farre et al. state that the study shows that "...a reduced cardiovascular activity and euphoria induced by MDMA were measured in the combination treatment (paroxetine and MDMA)."

     

    Finally, chronic use of SSRIs, as is done in the treatment of depression, seems to reduce the effects of MDMA. That is, a higher dose of MDMA is required to achieve the entactogenic effect.

     

     

    --------------------------------------------------------------------------------

     

    Nerve Cell Damage Protection?

     

    Some people take SSRIs (selective serotonin reuptake inhibitors) several hours after taking MDMA in an attempt to reduce or block suspected neurotoxicity (brain cell damage). See MDMA (Ecstasy) Neurotoxicity, by Baggott and Mendelson.

     

     

     

     

     

    --------------------------------------------------------------------------------

    Last Modified - Thu, Oct 6, 2005

    Rollingggggggggggggggg

    in Channel Zero

    Posted

    zoloft or any ssri (antidepressant that stimulates serotonin)

    is also good to extend the ecks.

     

    just be careful. you dumbass kids seem to think you're all invinsible these days.

     

     

     

    i was under the impression that ssri's made mdma less to non-effective?

     

     

    i havnt visted erowid in years though, so i don't really remember

    Graffitis Graphic Designers

    in Art & Design

    Posted

    I usually don't liek most designs nowadays but your shit is very clean and nice. Good job and keep up the good work. Whatever happened to the homie kOmega ??? haven't talked to him in a grip.

     

     

    i see him pop up on aim every once in a while but i never talk to him

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