KILZ FILLZ Posted November 17, 2020 Share Posted November 17, 2020 https://www.eurekalert.org/pub_releases/2020-11/udg-lba111320.php Swiss and Italian scientists prove a correlation between gut microbiota and the appearance of amyloid plaques in the brain, typical of Alzheimer's disease UNIVERSITÉ DE GENÈVE NEWS RELEASE 13-NOV-2020 Alzheimer's disease is the most common cause of dementia. Still incurable, it directly affects nearly one million people in Europe, and indirectly millions of family members as well as society as a whole. In recent years, the scientific community has suspected that the gut microbiota plays a role in the development of the disease. A team from the University of Geneva (UNIGE) and the University Hospitals of Geneva (HUG) in Switzerland, together with Italian colleagues from the National Research and Care Center for Alzheimer's and Psychiatric Diseases Fatebenefratelli in Brescia, University of Naples and the IRCCS SDN Research Center in Naples, confirm the correlation, in humans, between an imbalance in the gut microbiota and the development of amyloid plaques in the brain, which are at the origin of the neurodegenerative disorders characteristic of Alzheimer's disease. Proteins produced by certain intestinal bacteria, identified in the blood of patients, could indeed modify the interaction between the immune and the nervous systems and trigger the disease. These results, to be discovered in the Journal of Alzheimer's Disease, make it possible to envisage new preventive strategies based on the modulation of the microbiota of people at risk. The research laboratory of neurologist Giovanni Frisoni, director of the HUG Memory Centre and professor at the Department of Rehabilitation and Geriatrics of the UNIGE Faculty of Medicine, has been working for several years now on the potential influence of the gut microbiota on the brain, and more particularly on neurodegenerative diseases. «We have already shown that the gut microbiota composition in patients with Alzheimer's disease was altered, compared to people who do not suffer from such disorders,» he explains. «Their microbiota has indeed a reduced microbial diversity, with an over-representation of certain bacteria and a strong decrease in other microbes. Furthermore, we have also discovered an association between an inflammatory phenomenon detected in the blood, certain intestinal bacteria and Alzheimer's disease; hence the hypothesis that we wanted to test here: could inflammation in the blood be a mediator between the microbiota and the brain? » The brain under influence Intestinal bacteria can influence the functioning of the brain and promote neurodegeneration through several pathways: they can indeed influence the regulation of the immune system and, consequently, can modify the interaction between the immune system and the nervous system. Lipopolysaccharides, a protein located on the membrane of bacteria with pro-inflammatory properties, have been found in amyloid plaques and around vessels in the brains of people with Alzheimer's disease. In addition, the intestinal microbiota produces metabolites - in particular some short-chain fatty acids - which, having neuroprotective and anti-inflammatory properties, directly or indirectly affect brain function. «To determine whether inflammation mediators and bacterial metabolites constitute a link between the gut microbiota and amyloid pathology in Alzheimer's disease, we studied a cohort of 89 people between 65 and 85 years of age. Some suffered from Alzheimer's disease or other neurodegenerative diseases causing similar memory problems, while others did not have any memory problems,» reports Moira Marizzoni, a researcher at the Fatebenefratelli Center in Brescia and first author of this work. «Using PET imaging, we measured their amyloid deposition and then quantified the presence in their blood of various inflammation markers and proteins produced by intestinal bacteria, such as lipopolysaccharides and short-chain fatty acids.» A very clear correlation «Our results are indisputable: certain bacterial products of the intestinal microbiota are correlated with the quantity of amyloid plaques in the brain,» explains Moira Marizzoni. «Indeed, high blood levels of lipopolysaccharides and certain short-chain fatty acids (acetate and valerate) were associated with both large amyloid deposits in the brain. Conversely, high levels of another short-chain fatty acid, butyrate, were associated with less amyloid pathology.» This work thus provides proof of an association between certain proteins of the gut microbiota and cerebral amyloidosis through a blood inflammatory phenomenon. Scientists will now work to identify specific bacteria, or a group of bacteria, involved in this phenomenon. A strategy based on prevention This discovery paves the way for potentially highly innovative protective strategies - through the administration of a bacterial cocktail, for example, or of pre-biotics to feed the «good» bacteria in our intestine. «However, we shouldn't be too quick to rejoice,» says Frisoni. «Indeed, we must first identify the strains of the cocktail. Then, a neuroprotective effect could only be effective at a very early stage of the disease, with a view to prevention rather than therapy. However, early diagnosis is still one of the main challenges in the management of neurodegenerative diseases, as protocols must be developed to identify high-risk individuals and treat them well before the appearance of detectable symptoms.» This study is also part of a broader prevention effort led by the UNIGE Faculty of Medicine and the HUG Memory Centre. 2 Quote Link to comment Share on other sites More sharing options...
KILZ FILLZ Posted November 17, 2020 Author Share Posted November 17, 2020 I first leaned about gut microbiome about five years ago from Joshua Fields Millburn while he was discussing his use of diet to combat his various scalp issues never would’ve thought it would be tied to Alzheimer’s 1 Quote Link to comment Share on other sites More sharing options...
KILZ FILLZ Posted November 17, 2020 Author Share Posted November 17, 2020 Would you be willing to change your diet for the rest of your life to avoid dementia? 1 Quote Link to comment Share on other sites More sharing options...
Dirty_habiT Posted November 17, 2020 Share Posted November 17, 2020 Yep, absofuckinlutely I would. I'm already afraid of the stuff I have consumed up to this point affecting my health in the future. 1 Quote Link to comment Share on other sites More sharing options...
KILZ FILLZ Posted November 17, 2020 Author Share Posted November 17, 2020 I guess we are gonna have to learn to like pro-biotics lol. I can’t stand the flavor but better a little shot of that then a diet of kimchi and sauerkraut 😆 1 Quote Link to comment Share on other sites More sharing options...
Dirty_habiT Posted November 17, 2020 Share Posted November 17, 2020 Actually.... you just made me think of a good Reuben sandwich. I don't mind yogurt as long as it has all kinds of other shit mixed into it, vanilla flavor yogurt is best for that IMO..... I could probably stand to eat more of it. Quote Link to comment Share on other sites More sharing options...
Dirty_habiT Posted November 17, 2020 Share Posted November 17, 2020 Also, on the same tip, i've been EXTREMELY wary of taking any antibiotics for anything. Doctors work in medical "practices". That is very telling to me and that combined w/ my experiences has led me to be very cautious about accepting whatever a doctor tells me. For the same reason I won't be getting any vaccines. I haven't had the flu in like.... ever, or a flu shot..... so I dunno what that means to anyone following along here. I'm not even afraid of the flu at all and the people that I always hear talking about flu shots are the ones always sick. I dunno wtf to get from that other than I'm going to continue doing what I've been doing that has been working for me.... which is not getting a flu shot. This is also going to make a lot of people that like to point fingers and make fun of "anti vaxers" look real stupid when they end up with some stupid shit. You see the class action lawsuits for this all the time on tv commercials. I don't consider myself an "anti vaxxer" because i think that's a stupid name. I'm more of an anti you don't know what the fuck you're doing so you're not touching me'er. Quote Link to comment Share on other sites More sharing options...
KILZ FILLZ Posted November 17, 2020 Author Share Posted November 17, 2020 When you are seeing your general physician, you are basically paying them for their best educated guess. These are my symptoms, this is what I’ve been doing, this is how I am feeling then they lead you down the path the believe is best. pretty wild when I first heard it layed out that way. These dudes go to school for like 15 extra years to give you their best educated guess lol. Even on a more extreme level when you think of taking your pet to a veterinary. The pet can’t even give them those breadcrumbs. It’s basically, “yeah my cats been acting like a bitch, not sure what’s up. Can you help?” 😂 1 Quote Link to comment Share on other sites More sharing options...
Dirty_habiT Posted November 17, 2020 Share Posted November 17, 2020 I REALLY think that advertising medications should not be a thing at all. If you're fucked up go tell the doctor, the tv shouldn't solicit drugs to you like a crack dealer at the stop light in a shady neighborhood. Quote Link to comment Share on other sites More sharing options...
metronome Posted November 17, 2020 Share Posted November 17, 2020 1 hour ago, KILZ FILLZ said: Would you be willing to change your diet for the rest of your life to avoid dementia? Yes. GO SCIENCE GO 1 1 Quote Link to comment Share on other sites More sharing options...
misteraven Posted November 17, 2020 Share Posted November 17, 2020 Blew my mind to find out that supposedly to become a doctor, you aren’t required to take any classes on nutrition. Yet, we’ve all heard so many times, “you are what you eat”. That said, time to revisit my keto diet plans. Hardest part of changing your diet isn’t necessarily eating something different but meal planning. If you don’t plan, you’ll likely fall back to convenience and convenient food is some of the worst shit for you. At least as far as how most supermarkets are stocked. 1 Quote Link to comment Share on other sites More sharing options...
mr.yuck Posted November 18, 2020 Share Posted November 18, 2020 @misteraventhats the damn truth. Ive been working the past year to try and eat only foods that I make at home with non processed products. The shit is stupid hard. I have enough variety at the house to make 4 completely different go to dinners (thats all we eat). But the repetition gets boring as shit. Quote Link to comment Share on other sites More sharing options...
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