Smoke ... everyday in Channel Zero Posted December 4, 2009 I can't believe somebody suggested prescription pills as a substitute for weed. What a terrible idea. Especially if you have an addictive personality. Weed can be a substitute for anti-depressants, but not the other way around. I can't smoke weed regularly. California weed has gotten so potent, every time I smoke I feel like motherfuckers are staring at me.