i dont know about chemicals but as for weed and thc, that bentonite is sure fire. citro put me in jail, masks can be detected, bentonite is 100%. i had to piss every week, i would stop smoking two days before take that shit then piss and smoke right after i left probation. then repeat. i never had any dirtys. drinking water just masks thc, unless your a lil 100 pound fucker then that shit might work. but i have fat for the thc ti stick too.....