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http://my.webmd.com/content/article/97/104...0000_5024_hv_03

 

Human Test: Novel Vaccine Stops HIV

 

Treatment Turns On Anti-HIV Immunity, Holds AIDS Virus in Check

 

By Daniel DeNoon

WebMD Medical News Reviewed By Charlotte Grayson, MD

on Monday, November 29, 2004

 

 

 

 

 

 

Nov. 29, 2004 -- It worked in mice. It worked in monkeys. And now in humans, a therapeutic vaccine has stopped HIV in its tracks.

 

The vaccine is made from a patient's own dendritic cells and HIV isolated from the patient's own blood. Dendritic cells are crucial to the immune response. They grab foreign bodies in the blood and present them to other immune cells to trigger powerful immune system responses to destroy the foreign invaders.

 

HIV infection normally turns these important immune system responses off. But animal studies show that when dendritic cells are "loaded" with whole, killed AIDS viruses, they can trigger effective immune responses that keep infected animals from dying of AIDS.

 

Wei Lu, Jean-Marie Andrieu, and colleagues at the University of Paris in France and Pernambuco Federal University in Recife, Brazil, tested the vaccine on 18 Brazilian patients. All had HIV infection for at least a year. Their T-cell counts -- a crucial measure of AIDS progression -- were dropping, meaning their disease was worsening. None was taking anti-HIV medications.

 

After getting three under-the-skin injections of the tailor-made vaccine, the amount of HIV in the patients' blood (called the viral load) dropped by 80%. After a year, eight of the 18 patients still had a 90% drop in HIV levels. All patients' T-cell counts stopped dropping.

 

The findings appear in the December issue of Nature Medicine.

 

"The results suggest that [these] vaccines could be a promising strategy for treating people with chronic HIV infection," Andrieu and colleagues write. "The significant decrease of viral load as well as maintenance of ... [T-]cell counts observed at one year after immunization are particularly promising."

 

The researchers warn that their study is only proof of principle. It's still not clear which patients do best with the vaccine, although there's evidence that vaccination should be given as soon after HIV infection as possible. Only clinical trials comparing people who get the vaccine to those who don't can show whether this vaccine really is an effective AIDS therapy.

 

Similar approaches are being explored for the treatment of cancer and long-term viral infections such as hepatitis C.

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thats great news, but if you have aids you better get to a trial test soon, because once the treatment goes mainstream it will be so expensive that the majority of suffers will be unable to afford it.

lets hope the University of Paris will be socially responsible and not sell the patent to a large pharmaceutical company.

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survival of the fitest?

 

not taking something that is available to you that will make you better just because of the "survival of the fitest" thing would be retarded. that's like not eating, even though it would make you feel better, because you believe in survival of the fitest. i dunno.

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Originally posted by iloveboxcars@Dec 2 2004, 05:04 AM

survival of the fitest?

 

not taking something that is available to you that will make you better just because of the "survival of the fitest" thing would be retarded. that's like not eating, even though it would make you feel better, because you believe in survival of the fitest. i dunno.

 

yes, survival of the fitest...

 

giving somebody a cure, who was stupid enough to have unprotected sex with people who could possibly have aids and eating just for basic survival are completely different scenarios.

now if you got it through a transfusion or by other accidental methods, by all means go for the cure.

 

we're openning up quite the can of worms if we don't let mother nature take care of this planet like she has been since the beginning.

its not a perfect world, it never has been. but trying to make it perfect by eliminating all sickness and disease will actually do more harm than good in the long run....

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two things.....

 

pops.k has a valid argument but it's inhumane.

Human nature is to survive, even at the expense of nature.

We cant go against our own nature if we tried. I know.. it's a paradox.

 

secondly,

Rave Sex? More like 'meth head girls giving terrible teenage handjobs to limp dicks.'

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in other bad news.....

 

Aids 'will overwhelm wider world'

  • AIDS experts yesterday issued chilling warnings that India, China and Russia were on the brink of epidemics to parallel those in Africa.
     
    The virus was “perilously close to a tipping point” where it would explode across the population and spread “like wildfire”. The result would be “tens of millions of infections,” said Peter Piot, executive director of the United Nations agency UNAIDS.
     
    Speaking in Washington on the eve of World Aids Day, Mr Piot said that “no country on Earth will escape the impact” of the economic cost if the virus marched on at its current rate. By 2010, it would reach £8.8 billion a year.
     
    High-risk groups still dominate the Aids problem in Russia and China. But allowing the virus to leapfrog into the wider population as it has elsewhere could swallow up resources for African countries. HIV infections in Africa remain far higher than those in the Asia-Pacific nations. In China, 0.1 percent of people aged 15 to 49 are infected, compared with 7.5 per cent in sub-Saharan Africa.
     
    But that picture could change quickly. Mr Piot recalled that in South Africa the population affected doubled to 1 per cent in five years and then rocketed to 20 per cent in just seven years. India’s infection rate is also relatively low but the number of people infected, at 5.1 million, is second only to South Africa.
     
    The experts also criticised the focus on sexual abstinence in President Bush’s £7.7 billion Aids relief plan known as “ABC” — Abstinence, Being faithful and using Condoms.
     
    “Millions of women became infected while monogamous and faithful, so focusing solely on personal behaviour and risk absolutely does not go far enough,” said Geeta Rao Gupta, head of the International Centre for Research on Women. Mr Piot added: “Abstinence isn’t an option for women who are violated or abused. Our prevention strategies have to fit the realities of women’s lives. Marriage was not made for sexual abstinence.
     
    ” With the emphasis on prevention, the experts urged US policymakers to devote resources to strategies that would help women to protect themselves.
     
    These include microbicides to kill the virus, which women can use without their partner knowing, tougher punishments for rape and renewed efforts to reduce the incidence of child marriage.
     
    The number of women affected by HIV/Aids has increased steadily since 2002. Women now account for nearly half the estimated 37.2 million HIV-positive adults in the world.
     
    Even in America, Aids is the leading cause of death among African-American women between the ages of 25 and 34.

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for all those complaining "about time"

maybe you should think about prevention, education, and fucking DONATING to research efforts.

 

scientific research is tedious and time consuming.

AIDS is a biotch of a mutating virus that isn't going anywhere anytime soon.

 

it is up to the general population to "stop AIDS in it's tracks"

by preventing the spread of disease.

 

it is highly unlikely that there will be an elimination of all sickness either.

new diseases and viruses are emerging all the time,

especially as the human population grows into unreasonable numbers

and pushes the planet to the brink of sustenance.

 

just wait until BIRD FLU.

73% mortality rate.

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